Key Facts
An insulinoma is a rare, typically benign tumor of the pancreas that secretes excess insulin. This leads to frequent episodes of hypoglycemia, especially during fasting or exercise.
Pathophysiology
The tumor arises from beta cells in the pancreas. Unlike normal beta cells, insulinoma cells do not stop secreting insulin when blood glucose levels drop. This autonomous secretion causes persistent hyperinsulinemic hypoglycemia.
Symptoms & Clinical Features
Diagnosis
The "72-hour Fast" is the gold standard diagnostic test, where glucose, insulin, C-peptide, and pro-insulin are measured as hypoglycemia develops. Imaging (CT, MRI, or Endoscopic Ultrasound) is used to locate the tumor.
Diagnostic Pathway
Initial Screening
Symptom review and baseline hormonal blood tests.
Confirmatory Testing
Advanced diagnostic protocols (e.g., OGTT, MRI, Suppression tests).
Personalized Plan
Tailored treatment strategy based on clinical results.
Treatment & Management
Surgical removal (enucleation or partial pancreatectomy) is the curative treatment for most insulinomas. Medications like Diazoxide or Somatostatin analogs may be used to manage symptoms in patients who cannot undergo surgery.
Personalized treatment plans for your health.